While microarray technology is broadening its applications in genomics and proteomics, the technique remains a vibrant contributor in the area of gene expression. Much of the overall developmental ...
In this post-genomic era, drug discovery and other basic life science research sectors are increasingly utilizing nucleic acid microarrays for comprehensive gene expression studies. Drug discovery ...
Neuroblastomas is the most common extracranial solid tumour in children. The clinical behaviour of this tumour ranges from spontaneous regression to non-responsiveness to therapy. The molecular events ...
Serial analysis of gene expression (SAGE) uses mRNA from a sample to create complementary DNA (cDNA) fragments for amplification and sequencing using high-throughput sequencing technology. Credit: ...
BETHESDA, Md. (July 22, 2004) -- Microarray technology, sometimes referred to as biochips, has been extensively used to investigate genome-wide expression patterns and has facilitated a revolution in ...
Proof-of-principle experiments have described the use of oligonucleotide microarrays to profile transcript isoforms generated by alternative expression, but resources to create such arrays are lacking ...
The use of 18F-fluoroestradiol (FES) and 18F-fluorodeoxyglucose (FDG) PET in the evaluation of breast cancer heterogeneity. This is an ASCO Meeting Abstract from the 2017 ASCO Annual Meeting I. This ...
In the post-genomic era, long non-coding RNAs (lncRNAs) have emerged as critical regulators in various cancers and hold potential as minimally invasive diagnostic biomarkers. This study aimed to ...
Expression of the vascular endothelial growth factor family in tumor dissemination and disease free survival in clear cell renal cell carcinoma No significant financial relationships to disclose. This ...
Microarrays are used to detect the expression of a diverse range of thousands of genes. They include microscopic slides that can be printed with a spot of a known sequence of DNA. This sequence then ...
In each type of cell, like a muscle cell or a skin cell, different genes are expressed (turned on) or silenced (turned off). If the cells that are turned on mutate, they could—depending on what role ...
The research community's rapid acceptance of microarrays notwithstanding, technical challenges remain. Biochip developers continue to grapple with these issues while upgrading their offerings and ...
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